This article is a review of work published in Management Science on the topics of technological innovation, product development, and entrepreneurship since the inception of the journal in 1954. We intend the article to serve two goals. First, we hope that it will be useful to doctoral students and researchers interested in understanding what questions have been addressed in Management Science in the area of innovation. Second, we hope that the article will be useful to sociologists of science who are interested in understanding how knowledge develops in a field. We organize the literature into 12 themes. We then describe some aggregate properties of the articles. In an online supplement, we present brief summaries of the 250 articles we have identified as falling in the domain of our department.