Detection of potential enzyme targets by metabolic modelling and optimization: Application to a simple enzymopathy

Detection of potential enzyme targets by metabolic modelling and optimization: Application to a simple enzymopathy

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Article ID: iaor2009480
Country: United Kingdom
Volume: 23
Start Page Number: 2281
End Page Number: 2289
Publication Date: Jan 2007
Journal: Bioinformatics
Authors: , , ,
Keywords: programming: mathematical
Abstract:

A very promising approach in drug discovery involves the integration of available biomedical data through mathematical modelling and data mining. We have developed a method called optimization program for drug discovery (OPDD) that allows new enzyme targets to be identified in enzymopathies through the integration of metabolic models and biomedical data in a mathematical optimization program. The method involves four steps: (i) collection of the necessary information about the metabolic system and disease; (ii) translation of the information into mathematical terms; (iii) computation of the optimization programs prioritizing the solutions that propose the inhibition of a reduced number of enzymes and (iv) application of additional biomedical criteria to select and classify the solutions. Each solution consists of a set of predicted values for metabolites, initial substrates and enzyme activities, which describe a biologically acceptable steady state of the system that shifts the pathologic state towards a healthy state.

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