Article ID: | iaor20073793 |
Country: | United Kingdom |
Volume: | 34 |
Issue: | 3 |
Start Page Number: | 760 |
End Page Number: | 779 |
Publication Date: | Mar 2007 |
Journal: | Computers and Operations Research |
Authors: | Dijk Nico M. van, Wal Jan van der, Haijema Ren |
Keywords: | production, programming: dynamic, simulation: applications |
Blood platelets are precious, as voluntarily supplied by donors, and highly perishable, with limited lifetimes of 5–7 days. Demand is highly variable and uncertain. A practical production and inventory rule is strived for that minimizes shortages and spill. The demand and production are periodic, as varying over the seven days of the week. Demand for ‘young’ platelets (oncology and hematology) and demand for platelets of ‘any’ age up to the maximal shelf life (traumatology and general surgery) are distinguished. A combined Markov dynamic programming and simulation approach is presented and applied to a real life case of a Dutch blood bank. By down-sizing the dimension and applying this combined approach it is shown that order-up-to type replenishment rules that perform quite well can be found. Particularly, a double-level order-up-to rule, so-called 2