A minimum clique-transversal set MCT(G) of a graph G = (V,E) is a set S⊆V of minimum cardinality that meets all maximal cliques in G. A maximum clique-independent set MCI(G) of G is a set of maximum number of pairwise vertex-disjoint maximal cliques. We prove that the problem of finding an MCT(G) and an MCI(G) is NP-hard for cocomparability, planar, line and total graphs. As an interesting corollary we obtain that the problem of finding a minimum number of elements of a poset to meet all maximal antichains of the poset remains NP-hard even if the poset has height two, thereby generalizing a result of Duffas et al. We present a polynomial algorithm for the above problems on Helly circular-arc graphs which is the first such algorithm for a class of graphs that is not clique-perfect. We also present polynomial algorithms for the weighted version of the clique-transversal problem on strongly chordal graphs, chordal graphs of bounded clique size, and cographs. The algorithms presented run in linear time for strongly chordal graphs and cographs. These mark the first attempts at the weighted version of the problem.