In this paper, a generalized ‐subdifferential, which was defined by the radial epiderivative and a norm, is first introduced for a set‐valued mapping. Some existence theorems of the generalized ‐subdifferential and the radial epiderivative are discussed. A relationship between the existence of the radial epiderivative and the existence of the generalized ‐subdifferential is investigated for a set‐valued mapping.