Article ID: | iaor201523753 |
Volume: | 42 |
Issue: | 1 |
Start Page Number: | 306 |
End Page Number: | 328 |
Publication Date: | Mar 2015 |
Journal: | Scandinavian Journal of Statistics |
Authors: | Lu Xuewen, Song Peter X -K |
Keywords: | statistics: general, simulation: applications, medicine |
This paper focuses on efficient estimation, optimal rates of convergence and effective algorithms in the partly linear additive hazards regression model with current status data. We use polynomial splines to estimate both cumulative baseline hazard function with monotonicity constraint and nonparametric regression functions with no such constraint. We propose a simultaneous sieve maximum likelihood estimation for regression parameters and nuisance parameters and show that the resultant estimator of regression parameter vector is asymptotically normal and achieves the semiparametric information bound. In addition, we show that rates of convergence for the estimators of nonparametric functions are optimal. We implement the proposed estimation through a backfitting algorithm on generalized linear models. We conduct simulation studies to examine the finite‐sample performance of the proposed estimation method and present an analysis of renal function recovery data for illustration.