Severe disruption of the cytoskeleton and immunologically relevant surface molecules in a human macrophageal cell line in microgravity–Results of an in vitro experiment on board of the Shenzhou-8 space mission

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Article ID:	iaor20141047
Volume:	94
Issue:	1
Start Page Number:	277
End Page Number:	292
Publication Date:	Jan 2014
Journal:	Acta Astronautica
Authors:	Paulsen Katrin, Tauber Svantje, Goelz Nadine, Simmet Dana Michaela, Engeli Stephanie, Birlem Maria, Dumrese Claudia, Karer Anissja, Hunziker Sandra, Biskup Josefine, Konopasek Shalimar, Suh Durie, Hrlimann Eva, Signer Christoph, Wang Anna, Sang Chen, Grote Karl-Heinrich, Zhuang Fengyuan, Ullrich Oliver
Keywords:	biology

Abstract:

We investigated human macrophageal cells in long‐term microgravity.

We analyzed the cytoskeleton and immunologically relevant surface molecules.

The experiment was performed during the German‐Chinese SIMBOX/Shenzhou‐8 mission.

We found a severely disturbed actin cytoskeleton and disorganized tubulin.

We detected reduced expression of CD18, CD36 and MHC‐II.

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