Radiation hybrid map construction problem parameterized

Radiation hybrid map construction problem parameterized

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Article ID: iaor2014187
Volume: 27
Issue: 1
Start Page Number: 3
End Page Number: 13
Publication Date: Jan 2014
Journal: Journal of Combinatorial Optimization
Authors: , ,
Keywords: biology
Abstract:

In this paper, we study the Radiation hybrid map construction ( R H M C equ1 ) problem which is about reconstructing a genome from a set of gene clusters. The problem is known to be mathsf NP equ2 ‐complete even when all gene clusters are of size two and the corresponding problem ( R H M C 2 equ3 ) admits efficient constant‐factor approximation algorithms. In this paper, for the first time, we consider the more general case when the gene clusters can have size either two or three ( R H M C 3 equ4 ). Let p R H M C equ5 be a parameterized version of R H M C equ6 where the parameter is the size of solution. We present a linear kernel for p R H M C 3 equ7 of size 22 k equ8 that when combined with a bounded search‐tree algorithm, gives an FPT algorithm running in O ( 6 k k + n ) equ9 time. For p R H M C 3 equ10 we present a bounded search tree algorithm which runs in O * ( 2.45 k ) equ11 time, greatly improving the previous bound using weak kernels.

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