| Article ID: | iaor20132833 |
| Volume: | 157 |
| Issue: | 2 |
| Start Page Number: | 513 |
| End Page Number: | 519 |
| Publication Date: | May 2013 |
| Journal: | Journal of Optimization Theory and Applications |
| Authors: | Martinez-Morales Jose |
In this work, we define the optimal dose as a combination of the projections on orthogonal axes of the absorbed dose and an integer multiple of the integral dose. Here, we show that such optimal dose minimizes the mean square of the total absorbed dose subject to certain conditions of integration. We prove that there is a unique minimizer.