Optimal Impulsive Control Problem with Application to Human Immunodeficiency Virus Treatment

This paper describes an optimal control problem involving a nonlinear impulsive control system, together with a nonlinear objective function and nonlinear control and state constraints. Both the magnitude of the impulses as well as the instants at which the impulses are applied can be regarded as decision variables. A computational method is described for solving the problem. To illustrate the usefulness of our method for real‐life applications, we solve a Human Immunodeficiency Virus (HIV) treatment problem. The numerical results obtained clearly illustrate the efficiency of our method.