In statistical process control (SPC), when dealing with a quality characteristic x that is a variable, it is usually necessary to monitor both the mean value and variability. This article proposes an optimization algorithm (called the holistic algorithm) to design the CUSUM charts for this purpose. It facilitates the determination of the charting parameters of the CUSUM charts and considerably or significantly increases their overall detection effectiveness. A single CUSUM chart (called the ABS CUSUM chart) has been developed by the holistic algorithm and fully investigated. This chart is able to detect two-sided mean shifts and increasing variance shifts by inspecting the absolute value of sample mean shift. The results of performance studies show that the overall performance of the ABS CUSUM chart is nearly as good as an optimal 3-CUSUM scheme (a scheme incorporating three individual CUSUM charts). However, since the ABS CUSUM chart is easier for implementation and design, it may be more suitable for many SPC applications in which both mean and variance of a variable have to be monitored.