Palindromes in SARS and other coronaviruses

Palindromes in SARS and other coronaviruses

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Article ID: iaor2007226
Country: United States
Volume: 16
Issue: 4
Start Page Number: 331
End Page Number: 340
Publication Date: Sep 2004
Journal: INFORMS Journal On Computing
Authors: , , ,
Keywords: markov processes
Abstract:

With the identification of a novel coronavirus associated with the severe acute respiratory syndrome (SARS), computational analysis of its RNA genome sequence is expected to give useful clues to help elucidate the origin, evolution, and pathogenicity of the virus. In this paper, we study the collective counts of palindromes in the SARS genome along with all the completely sequenced coronaviruses. Based on a Markov-chain model for the genome sequence, the mean and standard deviation for the number of palindromes at or above a given length are derived. These theoretical results are complemented by extensive simulations to provide empirical estimates. Using a z score obtained from these mathematical and empirical means and standard deviations, we have observed that palindromes of length four are significantly underrepresented in all the coronaviruses in our data set. In contrast, length-six palindromes are significantly underrepresented only in the SARS coronavirus. Two other features are unique to the SARS sequence. First, there is a length-22 palindrome TCTTTAACAAGCTTGTTAAAGA spanning positions 25962–25983. Second, there are two repeating length-12 palindromes TTATAATTATAA spanning positions 22712–22723 and 22796–22807. Some further investigations into possible biological implications of these palindrome features are proposed.

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