In the binary single constraint Knapsack Problem, denoted KP, we are given a knapsack of fixed capacity c and a set of n items. Each item j, j= 1,…,n, has an associated size or weight wj and a profit pj. The goal is to determine whether or not item j, j= 1,…,n, should be included in the knapsack. The objective is to maximize the total profit without exceeding the capacity c of the knapsack. In this paper, we study the sensitivity of the optimum of the KP to perturbations of either the profit or the weight of an item. We give approximate and exact interval limits for both cases (profit and weight) and propose several polynomial time algorithms able to reach these interval limits. The performance of the proposed algorithms is evaluated on a large number of problem instances.