Article ID: | iaor20052214 |
Country: | Netherlands |
Volume: | 133 |
Issue: | 1 |
Start Page Number: | 277 |
End Page Number: | 283 |
Publication Date: | Jan 2005 |
Journal: | Annals of Operations Research |
Authors: | Wong K.H., Myburgh C. |
Keywords: | control processes |
We consider a computational approach to solving an optimal control formulation of optimal drug scheduling in HIV infected individuals. The optimal control problem is transformed using the control parameterisation enhancing technique (CPET), which enables efficient computation of an optimal control using a relatively coarse discretisation. A number of numerical difficulties with the model are discussed, and for illustration, numerical examples are solved.