Computational control of an HIV model

Computational control of an HIV model

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Article ID: iaor20052214
Country: Netherlands
Volume: 133
Issue: 1
Start Page Number: 277
End Page Number: 283
Publication Date: Jan 2005
Journal: Annals of Operations Research
Authors: ,
Keywords: control processes
Abstract:

We consider a computational approach to solving an optimal control formulation of optimal drug scheduling in HIV infected individuals. The optimal control problem is transformed using the control parameterisation enhancing technique (CPET), which enables efficient computation of an optimal control using a relatively coarse discretisation. A number of numerical difficulties with the model are discussed, and for illustration, numerical examples are solved.

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