A simulation to evaluate screening for Helicobacter pylori infection in the prevention of peptic ulcers and gastric cancers

A simulation to evaluate screening for Helicobacter pylori infection in the prevention of peptic ulcers and gastric cancers

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Article ID: iaor20031487
Country: Netherlands
Volume: 5
Issue: 4
Start Page Number: 249
End Page Number: 258
Publication Date: Nov 2002
Journal: Health Care Management Science
Authors: , , , , ,
Keywords: simulation: applications
Abstract:

A discrete event simulation model has evaluated a screening programme for Helicobacter pylori infection (H. pylori) in which individuals under the age of 50 years would be screened once. Eradication of H. pylori would reduce the peptic ulcer risk immediately and the gastric cancer risk after a fixed delay. The data were derived from published databases and peer reviewed papers. The simulation model, using variance reduction techniques, predicted that a screening programme would reduce morbidity and deaths but could cost around £19 million for England and Wales in the first year of screening. A factorial design analysis showed the sensitivity of key variables. An increase in the opportunistic testing was found significantly to reduce the impact of screening.

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