The classes of P-, P0-, R0-, semimonotone, strictly semimonotone, column sufficient, and non-degenerate matrices play important roles in studying solution properties of equations and complementarity problems and convergence/complexity analysis of methods for solving these problems. It is known that the problem of deciding whether a square matrix with integer/rational entries is a P- (or nondegenerate) matrix is co-NP-complete. We show, through a unified analysis, that analogous decision problems for the other matrix classes are also co-NP-complete.