DNA sequencing with positive and negative errors

DNA sequencing with positive and negative errors

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Article ID: iaor20002823
Country: United States
Volume: 6
Issue: 1
Start Page Number: 113
End Page Number: 123
Publication Date: Mar 1999
Journal: Journal of Computational Biology
Authors: , , ,
Keywords: programming: dynamic
Abstract:

The problem addressed in this paper is concerned with DNA sequencing by hybridization. An algorithm is proposed that solves a computational phase of this approach in the presence of both positive and negative errors resulting from the hybridization experiment. No a priori knowledge of the nature and source of these errors is required. An extensive set of computational experiments showed that the algorithm behaves suprisingly well if only positive errors appear. The general case, where positive and negative errors occur, can be also solved satisfactorily for an error rate up to 10%.

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