A dynamic HIV-transmission model for evaluating the costs and benefits of vaccine programs

A dynamic HIV-transmission model for evaluating the costs and benefits of vaccine programs

0.00 Avg rating0 Votes
Article ID: iaor19991287
Country: United States
Volume: 28
Issue: 3
Start Page Number: 146
End Page Number: 166
Publication Date: May 1998
Journal: Interfaces
Authors: , ,
Keywords: programming: dynamic
Abstract:

We developed a dynamic model of HIV transmission to evaluate the costs and benefits of HIV-vaccine programs in a population of homosexual men. We examined how changes in high-risk sexual behavior and the growth pattern of the epidemic influence the cost-effectiveness of preventive vaccines and of therapeutic vaccines. We found that the effect of reductions in condom use is more important for therapeutic vaccines than for preventive vaccines. Therapeutic vaccines may increase HIV seroprevalence in the population, unless the vaccine program is accompanied by increased condom use. Epidemic growth patterns also influence the cost-effectiveness of both vaccines, but the effects are more pronounced for preventive vaccines, which are more cost-effective in an early-stage epidemic than in a late-stage epidemic.

Reviews

Required fields are marked *. Your email address will not be published.