This paper discusses some recent developments in the theory of generalized functionals of Brownian motion. First it gives a brief summary of the Wiener-Ito multiple Integrals. It discusses some of their basic properties, and related functional analysis on Wiener measure space, then it discusses the generalized functionals constructed by Hida. The generalized functionals of Hida are based on L2-Sobolev spaces, thereby, admitting only Hs, s∈R valued kernels in the multiple stochastic integrals. These functionals are much more general than the classical Wiener-Ito class. The more recent development, due to the author, introduces a much more broad class of generalized functionals which are based on Lp-Sobolev spaces admitting kernels from the spaces 𝒲p’,s, s∈R. This allows analysis of a very broad class of nonlinear functionals of Brownian motion, which can not be handled by either the Wiener-Ito class or the Hida class. For s∈0, they represent generalized functionals on the Wiener measure space like Schwarz distributions on finite dimensional spaces. This paper also introduces some further generalizations, and constructs a locally convex topological vector space of generalized functionals. It also presents some discussion on the applications of these results.